JHU DREAMS Symposium | 2024
Liftoff+: Biotype-aware DNA Annotation Lift-over (2024)We generated an improved Ash1 genome annotation by leveraging the complete T2T-CHM13 reference, targeted liftover strategies, and curated handling of rDNA, VDJ, and protein-coding gene families for higher accuracy, especially on the Y chromosome. We produce a more complete and biologically reliable population-specific annotation, strengthening downstream genomic interpretation.